Death Jr.: Root of Evil takes on a whole new level of challenge and fun on the Wii, offering dual-weapon attack modes that give players complete control of the Wii Remote and Nunchuk in melee and ranged combat. With over 45 varieties of enemies, players will have their skills tested while swinging at nearby enemies in melee combat with the enhanced motion sensing on the Wii Remote using DJ's famed scythe or Pandora's whip. The versatility of the Wii Remote allows for precision targeting with active aiming to shoot down airborne, burrowing, distant or close combat enemies, and players can also unlock new attack combos, and build and upgrade projectile weapons. The intuitive camera system takes full advantage of the Wii Remote for direct, full-3D camera pointing and control for exploration.

Described as "Pokemon meets Tim Burton," Monster Lab features single player and multi-player modes, turn-based combat, minigames, and monster-building with a dazzling array of parts. Players assist one of three professors in order to build their own monster.